Structure of Two in Tandem Human 17β-Hydroxysteroid Dehydrogenase Genes
نویسندگان
چکیده
منابع مشابه
Expression patterns of 17β-hydroxysteroid dehydrogenase 14 in human tissues.
17βHSD enzymes catalyze the stereospecific oxidation/reduction at carbon 17β of androgens and estrogens, and are important players in intracrine sex hormone synthesis. The biological relevance of 17βHSD14, first named retSDR3, is largely unknown. We generated and validated an antibody targeting the 17βHSD14 antigen and used this for immunohistochemical evaluation of expression patterns in 33 he...
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Heterodera glycines Hg-hsd-1 and Hg-hsd-2 are two homologues of let-767, a short-chain dehydrogenase gene from the free-living nematode Caenorhabditis elegans. Both genes share similarity to 17β-hydroxysteroid dehydrogenases (17β-HSDs), enzymes known to be involved in the production of steroid hormones in mammals. Hg-hsd-1 and Hg-hsd-2 encode distinct protein sequences that share 51% amino acid...
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The objective of the present study was to investigate the effects of genistein and equol on 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3) in human and rat testis microsomes. These enzymes (3β-HSD and 17β-HSD3), along with two others (cytochrome P450 side-chain cleavage enzyme and cytochrome P450 17α-hydroxylase/17-20 lyase), catalyze the reactions th...
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17β-Hydroxysteroid dehydrogenase type 10 (17β-HSD10) is encoded by the HSD17B10 gene mapping at Xp11.2. This homotetrameric mitochondrial multifunctional enzyme catalyzes the oxidation of neuroactive steroids and the degradation of isoleucine. This enzyme is capable of binding to other peptides, such as estrogen receptor α, amyloid-β, and tRNA methyltransferase 10C. Missense mutations of the HS...
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BACKGROUND Diabetes is characterized by chronic hyperglycemia, and hyperglycemia can increase reactive oxygen species (ROS) production from the mitochondrial electron transport chain. The formation of ROS in cells induces oxidative stress and activates oxidative damage-inducing genes. There is no research on the protein levels of oxidative damage-related genes AKR1C3 in human diabetic skin. We ...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1990
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend-4-2-268